3p91 | pdb_00003p91

Crystal structure of Proliferating Cellular Nuclear Antigen from Entamoeba histolytica

spinqualitylabelsall models 3p91, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3p91 is a 1 chain structure with sequence from Enthi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: EHI_128450 (ENTHI) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [C4M9R9_ENTHI] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.[RuleBase:RU000641] Publication Abstract from PubMed Proliferating cellular nuclear antigen (PCNA) is a toroidal-shaped protein that is involved in cell-cycle control, DNA replication and DNA repair. Parasitic protozoa are early-diverged eukaryotes that are responsible for neglected diseases. In this work, a PCNA from a parasitic protozoon was identified, cloned and biochemically characterized and its crystal structure was determined. Structural and biochemical studies demonstrate that PCNA from Entamoeba histolytica assembles as a homotrimer that is able to interact with and stimulate the activity of a PCNA-interacting peptide-motif protein from E. histolytica, EhDNAligI. The data indicate a conservation of the biochemical mechanisms of PCNA-mediated interactions between metazoa, yeast and parasitic protozoa. Structure and biochemical characterization of proliferating cellular nuclear antigen from a parasitic protozoon.,Cardona-Felix CS, Lara-Gonzalez S, Brieba LG Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):497-505. Epub 2011 May 12. PMID:21636889 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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