3stm | pdb_00003stm

Structure of human LFABP in complex with one molecule of palmitic acid

spinqualitylabelsall models 3stm, resolution 2.22Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3stm is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PLM Related: 3stk, 3stn Gene: FABP1, FABPL (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Publication Abstract from PubMed We crystallized human liver fatty acid binding protein (LFABP) in apo, holo and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry and docking within LFABP support a heads in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling where first palmitate ingress creates atomic environment for placement of second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP. Fatty acid induced remodeling within the Human liver fatty acid binding protein.,Sharma A, Sharma A J Biol Chem. 2011 Jul 8. PMID:21757748 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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