4gr9 | pdb_00004gr9

Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation

spinqualitylabelsall models 4gr9, resolution 2.29Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4gr9 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 372, FAD, GOL, ZN Related: 4gqi Gene: NQO2, NMOR2 (HUMAN) Activity: Ribosyldihydronicotinamide dehydrogenase (quinone), with EC number 1.10.99.2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Publication Abstract from PubMed New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent yields via Knoevenagel condensation. The relative binding affinity of new synthesized compounds to MT3 receptor was tested via enzymatic assays and the X-ray structures of the most potent compounds were determined in complex with MT3. Synthesis of novel capital EM, Cyrilliccapital TE, Cyrillic3 receptor ligands via an unusual Knoevenagel condensation.,Volkova MS, Jensen KC, Lozinskaya NA, Sosonyuk SE, Proskurnina MV, Mesecar AD, Zefirov NS Bioorg Med Chem Lett. 2012 Dec 15;22(24):7578-81. doi:, 10.1016/j.bmcl.2012.10.005. Epub 2012 Oct 17. PMID:23131339 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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