4mlo | pdb_00004mlo

1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form)

spinqualitylabelsall models 4mlo, resolution 1.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4mlo is a 1 chain structure with sequence from "bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, PAM Gene: toxT ("Bacillo virgola del Koch" Trevisan 1884) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed ToxT is an AraC-family transcriptional activator protein that controls the expression of key virulence factors in Vibrio cholerae, the causative agent of cholera. ToxT directly activates the expression of the genes that encode the toxin-coregulated pilus and cholera toxin, and also positively auto-regulates its own expression from the tcp promoter. The crystal structure of ToxT has previously been solved at 1.9 A resolution (PDB entry 3gbg). In this study, a crystal structure of ToxT at 1.65 A resolution with a similar overall structure to the previously determined structure is reported. However, there are distinct differences between the two structures, particularly in the region that extends from Asp101 to Glu110. This region, which can influence ToxT activity but was disordered in the previous structure, can be traced entirely in the current structure. 1.65 A resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae.,Li J, Wehmeyer G, Lovell S, Battaile KP, Egan SM Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):726-31. doi:, 10.1107/S2053230X1601298X. Epub 2016 Aug 26. PMID:27599865 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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