2alv | pdb_00002alv
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| 2alv, resolution 1.90Å | |||||||||||||
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| Ligands: | CY6 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors
Overview
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
About this Structure
2ALV is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632
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