5ltd | pdb_00005ltd

Phosphate-bound Pichia angusta Atg18

spinqualitylabelsall models 5ltd, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5ltd is a 2 chain structure with sequence from Cbs 7073. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, PO4 Gene: ATG18 (CBS 7073) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ATG18_PICAN] The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

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