3c72 | pdb_00003c72

Engineered RabGGTase in complex with a peptidomimetic inhibitor

spinqualitylabelsall models 3c72, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3c72 is a 2 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, CX1, ZN Gene: Rabggta, Ggta (Buffalo rat), Rabggtb, Ggtb (Buffalo rat) Activity: Protein geranylgeranyltransferase type II, with EC number 2.5.1.60 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [PGTB2_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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