4bwj | pdb_00004bwj

KlenTaq mutant in complex with DNA and ddCTP

spinqualitylabelsall models 4bwj, resolution 1.55Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4bwj is a 3 chain structure with sequence from Atcc 25104. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: DCT, MG NonStd Res: DOC Related: 4bwm Activity: DNA-directed DNA polymerase, with EC number 2.7.7.7 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Unfaithful: The structure of a DNA-dependent DNA polymerase, whose parental ancestor has no significant reverse transcriptase activity, was obtained for the first time incorporating a nucleotide against an RNA template and then structurally characterized. The DNA polymerase variant has significant reverse transcriptase activity that allows its application in PCR-based molecular diagnostics. Structure and Function of an RNA-Reading Thermostable DNA Polymerase.,Blatter N, Bergen K, Nolte O, Welte W, Diederichs K, Mayer J, Wieland M, Marx A Angew Chem Int Ed Engl. 2013 Sep 17. doi: 10.1002/anie.201306655. PMID:24106012 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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