Cryptochrome

spinqualitylabelsall models Mouse cryptochrome-1 complex with FAD (PDB code 4i6g) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cryptochrome (Cry) is a flavoprotein associated with the biological clock function. In Drosophila melanogaster it is also involved in blue-light photoreception. Disease The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer.

3D Structures of cryptochrome

Updated on 20-November-2017

4i6e, 4k0r, 5t5x – mCry-1 – mouse
4jzy, 4gu5, 4k03 – Cry-1 + FAD – Drosophila melanogaster
1u3c – AtCry-1 PHR domain + FAD - Arabidopsis thaliana
1u3d – AtCry-1 PHR domain + FAD + AMPPNP
4ct0 – mCry-1 + PER2
4i6g – mCry-2 + FAD
4u8h – mCry-2 + PER2
4mlp – mCry-2 + carbazol derivative
3zxs – Cry-2 + FAD – Rhodobacter sphaeroides
2j4d, 2ijg – AtCry-3 + FAD
2vtb – AtCry-3 + FAD + DNA
3fy4 – AtCry 6-4 + FAD
1np7 – Cry - Synechocystis

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Michal Harel, Alexander Berchansky, Joel L. Sussman