2bdy | pdb_00002bdy
From Proteopedia
thrombin in complex with inhibitor
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| 2bdy, resolution 1.610Å | |||||||||||||
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| Ligands: | NA, TYS, UNB | ||||||||||||
| Activity: | Thrombin, with EC number 3.4.21.5 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.
About this Structure
2BDY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure., Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellstrom O, Xue Y, Bioorg Med Chem Lett. 2006 Feb 15;16(4):1032-6. Epub 2005 Nov 15. PMID:16290930
Page seeded by OCA on Mon Mar 31 02:04:56 2008
