4u5a | pdb_00004u5a

Sporozoite Protein for Cell Traversal

spinqualitylabelsall models 4u5a, resolution 2.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4u5a is a 4 chain structure with sequence from Plabe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: spect (PLABE) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Host cell traversal by Plasmodium, the protozoan cause of malaria, is an essential part of this parasite's virulence. In this process, the parasite enters a host cell through a parasite-induced pore, traverses the host cell, and then exits the host cell. Two P. berghei proteins, SPECT1 and SPECT2, are required for host cell traversal by the sporozoite form of the parasite. In the absence of either, no pore formation is observed. While SPECT2 has sequence homology to pore-forming proteins, SPECT1 has no homology to proteins of known structure or function. Here we present the 2.75 A resolution structure of a slightly truncated version of P. berghei SPECT1. The structure reveals that the protein forms a four-helix bundle, with the rare feature of having all of these helices in parallel or antiparallel alignment. Also notable is the presence of a large, conserved, hydrophobic internal cavity in the protein, which may constitute a ligand-binding site or be indicative of partial instability in SPECT1, or both. The structure of SPECT1 will make possible targeted mutagenesis experiments aimed at understanding its mechanism of action in host cell traversal. Structure of the Essential Plasmodium Host Cell Traversal Protein SPECT1.,Hamaoka BY, Ghosh P PLoS One. 2014 Dec 5;9(12):e114685. doi: 10.1371/journal.pone.0114685., eCollection 2014. PMID:25479287 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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