6bf2 | pdb_00006bf2

Solution structure of a Bcl-xL S62E mutant

spinqualitylabelsall models 6bf2, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6bf2 is a 1 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 5l1y. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: BCL2L1, BCL2L, BCLX (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis.

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