Radixin

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Radixin (Rdx) plays an important role in promoting cell migration by regulating Rac-1-mediated epithelial polarity and formation of adherens junctions through Rac guanine nucleotide exchange factors. Rdx is part of the ERM (Ezrin/Radixin/Moesin) which is linked to cell shape change. Phosphorylation of the C-terminal Thr residues of ERM inhibits cell adhesion and induces formation of spherical cell shape. Disease Rdx deficiency causes increase in bilirubin in serum, a phenotype similar to that of Dubin-Johnson syndrome in human.

3D Structures of radixin

Updated on 25-December-2017

1gc7, 2d2q – mRad FERM domain – mouse
3x23, 2ems, 2yvc, 2d10, 2d11, 2emt, 1j19, 2zpy – mRad FERM domain + peptide
1gc6 – mRad FERM domain + inositol-triphosphate

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Michal Harel, Alexander Berchansky, Joel L. Sussman