2duv | pdb_00002duv
From Proteopedia
Structure of CDK2 with a 3-hydroxychromones
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| 2duv, resolution 2.2Å | |||||||||||||
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| Ligands: | 371 | ||||||||||||
| Activity: | Cyclin-dependent kinase, with EC number 2.7.11.22 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
About this Structure
2DUV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224
Page seeded by OCA on Mon Mar 31 02:39:51 2008
