Mutation:BRCA1

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Germline mutations in the BRCA1 tumor suppressor gene often result in a significant increase in susceptibility to breast and ovarian cancers. Although the molecular basis of their effects remains largely obscure, many mutations are known to target the highly conserved C-terminal BRCT repeats that function as a phosphoserine/phosphothreonine-binding module. The most common cause of monogenic disease is a single base DNA variant resulting in an amino acid substitution. A set of structural effects, such as reduction in hydrophobic area, overpacking, backbone strain, and loss of electrostatic interactions, is used to represent the impact of single residue mutations on protein stability. The distinction between disease and non-disease variants, strongly supports the hypothesis that loss of protein stability is a major factor contributing to monogenic disease. ToDo: cleanup elements between mutations display ToDo: use ConSurf colouring on structure. ToDo: Implement Template to render ALL mutations of a given model with ConSurf colouring. ToDo: Check if model(s) structure loaded before displaying a mutation, to enable showing other structures and back to the sequence/model interaction. Currently model(s) structure loaded only on initial page loading. ToDo: extend to support more than one mutation in same residue ToDo: implement bidirectional action between sequence and model ToDo: display icons + text associated to the kind of mutation (echo or below applet) ToDo: implement a tooltip-style text box holding additional information for each mutation ToDo: implement storage of all accessory information per residue

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John Moult, Jaime Prilusky, Angel Herraez, Lipika Ray, Joel L. Sussman