5muo | pdb_00005muo

X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with propofol

spinqualitylabelsall models 5muo, resolution 3.19Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5muo is a 5 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACT, CL, LMT, PFL Related: 3tls, 3tlt, 3tlu, 3tlw Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.

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