5uqu | pdb_00005uqu

Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus

spinqualitylabelsall models 5uqu, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5uqu is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: COA, OAA, SO4 Related: 5uqo, 5uqq, 5uqr, 5uqs Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PRPC_ASPFM] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.

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