5uys | pdb_00005uys

Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog

spinqualitylabelsall models 5uys, resolution 2.39Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5uys is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 8QD, HEM Related: 4nkv, 4nkw, 4nkx, 4nky, 4nkz, 3ruk, 3swz Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [CP17A_HUMAN] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry. Function [CP17A_HUMAN] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

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