2f6v | pdb_00002f6v
Protein tyrosine phosphatase 1B with sulfamic acid inhibitors
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| 2f6v, resolution 1.70Å | |||||||||||||
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| Ligands: | CL, MG, SK2 | ||||||||||||
| Gene: | PTPN1, PTP1B (Homo sapiens) | ||||||||||||
| Activity: | Protein-tyrosine-phosphatase, with EC number 3.1.3.48 | ||||||||||||
| Related: | 2F6T, 2F6W, 2F6Y, 2F6Z, 2F70, 2F71
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
About this Structure
2F6V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors., Klopfenstein SR, Evdokimov AG, Colson AO, Fairweather NT, Neuman JJ, Maier MB, Gray JL, Gerwe GS, Stake GE, Howard BW, Farmer JA, Pokross ME, Downs TR, Kasibhatla B, Peters KG, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1574-8. Epub 2006 Jan 4. PMID:16386905
Page seeded by OCA on Mon Mar 31 02:58:47 2008
