5v03 | pdb_00005v03

A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA

spinqualitylabelsall models 5v03, resolution 1.58Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5v03 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 658, CA, SO4 Related: 5v02 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [KCNN2_HUMAN] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

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