2v02 | pdb_00002v02

Recombinant vertebrate calmodulin complexed with Ba

spinqualitylabelsall models 2v02, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2v02 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BA, CA Related: 1aji, 1cdl, 1cll, 1ctr, 1iwq, 1j7o, 1j7p, 1k90, 1k93, 1l7z, 1lvc, 1nkf, 1pk0, 1s26, 1sk6, 1sw8, 1wrz, 1xfu, 1xfv, 1xfw, 1xfx, 1xfy, 1xfz, 1y6w, 1yr5, 1yrt, 1yru, 1zot, 2be6, 2f3y, 2f3z, 2v01 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans. A structural insight into lead neurotoxicity and calmodulin activation by heavy metals.,Kursula P, Majava V Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):653-6. Epub 2007 Jul 28. PMID:17671360 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Calmodulin

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