5i07 | pdb_00005i07

tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 6-Amino-4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

spinqualitylabelsall models 5i07, resolution 1.89Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5i07 is a 2 chain structure with sequence from Zymmo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, GOL, NE8, ZN Related: 1y5v, 4kwo, 4leq, 4puk, 5i00, 5i02, 5i06, 3eos, 3ge7, 1y5x, 1y5w, 4fsa, 4fr6, 1p0d Gene: tgt, ZMO0363 (ZYMMO) Activity: tRNA-guanine(34) transglycosylase, with EC number 2.4.2.29 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

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