2fw3 | pdb_00002fw3
From Proteopedia
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| 2fw3, resolution 2.50Å | |||||||||||||
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| Ligands: | BUI | ||||||||||||
| Activity: | Carnitine O-palmitoyltransferase, with EC number 2.3.1.21 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326
Overview
Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
About this Structure
2FW3 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:16615901
Page seeded by OCA on Mon Mar 31 03:08:24 2008
