BRCA

spinqualitylabelsall models Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code 3coj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see: RING Finger Domain of BRCA1 and BARD1 Heterodimer. Mutations in BRCA1/BARD1 RING-domain heterodimer. Mutations in Brca1 BRCT Domains. Disease Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers. Structural highlights The phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains. These domains contain most of the mutations seen in BRCA1. Phosphoserine binding.

3D structures of BRCA1

Updated on 03-April-2018

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• • RING Finger Domain of BRCA1 and BARD1 Heterodimer, Mutations in BRCA1/BARD1 RING-domain heterodimer, Mutations in Brca1 BRCT Domains, 4u4a, 4jlu, 4ifi, 4igk, 3k0h, 3k0k, 3coj, 1y98, 1t15, 1t29, 1t2v - hBRCA1 BRCT1 domain + peptide inhibitor - human
    
  • 3pxa, 3pxb, 3pxc, 3pxd, 3pxe, 3k15, 3k16 - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor
    
  • 1jnx - hBRCA1 BRCT domain
    
  • 2ing, 1t2u, 1n5o - hBRCA1 BRCT1 domain (mutant)
    
  • 1oqa - hBRCA1 BRCT-C domain - NMR
    
  • 1l0b - BRCA1 BRCT domain - rat
    
  • 2n9e - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR
    
  • 4mkf, 4mkg - hBRCA1 SUMO-interacting motif - NMR
    
  • 1jm7 - hBRCA1 Ring domain + BARD1 ring domian - NMR
    
• BRCA2
  • 1iyj, 1miu – hBRCA2 residues 2335-3151 + DSS1
    
  • 1mje – hBRCA2 residues 2335-3151 + DSS1 + ssDNA
    
  • 1n0w – hBRCA2 BRC repeat 4 + RAD51 + linker
    

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman