Cellobiohydrolase

spinqualitylabelsall models Glycosylated cellobiohydrolase I catalytic domain complex with cellobiose and Cd+2 ions (yellow) (PDB code 3cel) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cellobiohydrolase (CBH) is a cellulase which degrades cellulose by hydrolysing the 1,4-β-D-glycosidic bonds. CBH is an exocellulase which cleaves two to four units from the ends of cellulose. There are two types of CBH. CBHI cleaves progressively from the reducing end while CBHII cleaves progressively from the nonreducing end of cellulose.. The exo-acting CBH I is called Cel7A. The endo-acting CBH I is called Cel7B. Structural highlights The active site of CBH contains Glu-Asp-Glu (Gln-Asp-Glu in 3cel, cyan) and is situated at the bottom of a tunnel.

3D structures of cellobiohydrolase

Updated on 09-April-2018

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• Cellobiohydrolase I

• • 3cel, 4p1h, 4p1j – HjCBHI Cel7A catalytic domain – Hypocrea jecorina
    
  • 2cel, 4cel, 1egn, 1q2b - HjCBHI catalytic domain (mutant)
    
  • 1cbh, 2cbh – HjCBHI C terminal – NMR
    
  • 1azh, 1az6, 1azj, 1azk - HjCBHI cellulose-binding domain (mutant) - NMR
    
  • 1gpi - PcCBHI Cel7D catalytic domain – Phanerochaete chrysosporium
    
  • 1q9h, 3pfj - TeCBHI Cel7A catalytic domain – Talaromyces emersonii
    
  • 2yok, 2y9n - CBHI Cel7A catalytic domain – Hypocrea lixii
    
  • 5mcc, 5mcd, 5mce, 5mcf, 5mch, 5mci, 5mcj, 5mck, 5mcl, 5mcm, 5mcn, 4xnn – wfCBHI – water flea
    
  • 4zzv, 5amp - GcCBHI Cel7A catalytic domain – Galactomyces candidum
    
• Cellobiohydrolase I binary complex
  • 3cel - HjCBHI Cel7A catalytic domain (mutant) + cellobiose
    
  • 5cel, 1q2e - HjCBHI Cel7A catalytic domain (mutant) + cellotetraose
    
  • 6cel - HjCBHI Cel7A catalytic domain (mutant) + cellopentaose
    
  • 7cel - HjCBHI catalytic domain (mutant) + glucose
    
  • 2v3i, 2v3r - HjCBHI Cel7A catalytic domain + phenanthrenolol
    
  • 1dy4 - TrCBHI Cel7A catalytic domain + propranolol – Trichoderma reesei
    
  • 1h46 - PcCBHI Cel7D catalytic domain + propranolol
    
  • 1z3t - PcCBHI Cel7D catalytic domain + cellobiose
    
  • 1z3v - PcCBHI Cel7D catalytic domain + lactose
    
  • 1z3w - PcCBHI Cel7D catalytic domain + cellobioimidazole
    
  • 3pfx - TeCBHI Cel7A catalytic domain + cellobiose
    
  • 3pfz - TeCBHI Cel7A catalytic domain + cellotetraose + cellobiose
    
  • 3pl3 - TeCBHI Cel7A catalytic domain + cellopentaose
    
  • 4zzu - GgCBHI Cel7A catalytic domain + cellotetraose – Galactomyces geotrichum
    
  • 4zzw - GgCBHI Cel7A catalytic domain + cellobiose
    
  • 4zzt - GcCBHI Cel7A catalytic domain + cellotraiose
    
• Cellobiohydrolase II
  • 3cbh – HjCBHII core
    
  • 1cb2 – HjCBHII catalytic domain (mutant)
    
  • 1hgw, 1hgy, 1oc6 – HjCBHII Cel6A catalytic domain (mutant)
• Cellobiohydrolase II binary complex
  • 1bvw - HiCBHII catalytic domain + mannose – Humicola insolens
    
  • 2bvw - HiCBHII Cel6A catalytic domain + glucose + cellotetraose
    
  • 1gz1, 1oc5 - HiCBHII Cel6A catalytic domain (mutant) + cellotetraose
    
  • 1oc7 - HiCBHII Cel6A catalytic domain (mutant) + cellopentaose
    
  • 1ocj - HiCBHII Cel6A catalytic domain + cellopentaose
    
  • 1ocb - HiCBHII Cel6A catalytic domain + fluorescent substrate
    
  • 1ocn - HiCBHII Cel6A catalytic domain (mutant) + isofagomine
    
  • 1qjw - TrCBHII Cel6A catalytic domain (mutant) + cellotetraose
    
  • 1qk0 - TrCBHII Cel6A catalytic domain + polysaccharide
    
  • 1qk2 - TrCBHII Cel6A catalytic domain + cellotetraose
    
• Other cellobiohydrolases
  • 1l1y – CtCBH CelS – Clostridium thermocellum
    
  • 1rq5 - CtCBHA (mutant)
    
  • 1ut9 - CtCBHA catalytic domain
    
  • 1sqj - GgCBH
    
  • 3a64, 3vog - CcCBH Cel6C catalytic domain - Coprinopsis cinerea
    
  • 3vof, 3voj - CcCBHI Cel6C catalytic domain (mutant)
    
  • 4v1z – AfCBH Cel7A – Aspergillus fumigatus
    
• Other cellobiohydrolases binary complex
  • 1l2a - CtCBH CelS + glucose
    
  • 2ebs – GgCBH (mutant) + heptasaccharide
    
  • 3a9b, 3voh - CcCBHI Cel6C catalytic domain + cellobiose
    
  • 3abx, 3voi - CcCBHI Cel6C catalytic domain + cellotriose
    
  • 4v20 - AfCBH Cel7A + disaccharide
    
  • 4v0z - TrCBH Cel7A + cellobiose
    
  • 4vwt - TrCBH Cel7A (mutant) + cellobiose
    

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Michal Harel, Alexander Berchansky, Karsten Theis