Cyclin

spinqualitylabelsall models Cyclin T1 (green) complex with CDK9 (cyan) and TRIS (PDB entry 3blh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cyclin (CYC) activates CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that different CYCs are expressed during different phases of the cell cycle. Among the CYCs, CYCA is active in the S phase, CYCD regulate the transition from G1 to S. See also Intrinsically Disordered Protein. Structural highlights All cyclins have an all-α helix fold and share an identical ca. 100 residue domain called 'cyclin box' which binds CDK. Two 5 α-helix cyclin boxes are shown.

3D Structures of Cyclin

Updated on 17-April-2018

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• CYCA2
  • Intrinsically Disordered Protein, 2wpa, 2wxv, 2wih, 2wip, 3f5x, 3eoc, 3eid, 3ej1, 3dog, 3ddp, 3ddq, 3bht, 2v22, 2uue, 2i40, 2bkz, 2c5n, 2c5o, 2c5v, 2c5x, 2c5y, 2bpm, 2c4g, 1fvv, 2c6t – hCYCA2 +CDK2+inhibitor - human
    
  • 3bhu, 3bhv, 2uzd, 2uzb, 2uze, 2uzl, 2uzn, 2uzo, 2iw6, 2iw8, 2iw9, 2g9x, 1oi9, 1oiu, 1oiy, 1ogu, 1p5e, 1pkd, 1h1p, 1h1q, 1h1r, 1h1s, 4cfx, 4cfv, 4cfu, 4cfm, 5nev, 5nev, 5lmk, 5cyi - hCYCA2 +CDK2 T160P+inhibitor
    
  • 1fin, 5if1 - hCYCA2 +CDK2
    
  • 1vyw - hCYCA2 C-terminal + hCDK2
    
  • 1jst, 3tnw - hCYCA2 +CDK2 T160P
    
  • 1h24, 1h25, 1h26, 1h27, 1h28, 1gy3 - hCYCA2 +CDK2 T160P+peptide
    
  • 4bck, 4bcm, 4bcn, 4bco, 4bcp, 4bcq, 4cfn, 4cfw - hCYCA2 +CDK2 T160P + inhibitor
    
  • 4fx3 - hCYCA2 +CDK2 + inhibitor
    
  • 4eoi, 4eoj, 4eok, 4eol, 4eom, 4eon, 4eoo, 4eop, 4eoq, 4eor, 4eos - hCYCA2 C-terminal +CDK2 T160P + inhibitor
    
  • 2cjm - hCYCA2 +CDK2 T160P Y15P
    
  • 2cch - hCYCA2 +CDK2 T160P+ATP analog
    
  • 4i3z, 4ii5 - hCYCA2 +CDK2 T160P+ADP + Mg
    
  • 2cci - hCYCA2 +CDK2 T160P+CDC homolog
    
  • 2wma, 2wmb, 2x1n, 2wev, 2wfy, 2whb, 1okv, 1okw, 1ol1, 1ol2, 1urc, 1qmz, 3qhw - hCYCA2 +CDK2+peptide
    
  • 1jsu - hCYCA2 +CDK2 (mutant)+P27
    
  • 3qhr, 3khw - CYCA2 + P33 protein kinase + CDK2 peptide – mouse
• CYCA3
  • 1vin – CYCA3 - bovine
    
  • 1e9h – hCYCA3 +CDK2 T160P+inhibitor
    
• CYCB1
  • 2b9r – hCYCB1 (mutant)
    
  • 2jgz - hCYCB1 + CDK2
    
  • 5hq0, 4yc3, 4y72 – hCYCB1 + hCDK1 + CDK regulatory subunit 2
    
  • 5lqf – hCYCB1 + hCDK1 + CDK regulatory subunit 2 + inhibitor
    
• CYCC
  • 3rgf, 4g6l – hCYCC + CDK8
    
  • 4f6s, 4f6u, 4f6w, 4f70, 4f7j, 4f7l, 4f7n, 4f7s, 5idp, 5idn, 5icp, 5i5z, 5hvy, 5hnb, 5hbj, 5hbh, 5hbe, 5fgk, 5cei, 5bnj, 5xqx, 5xs2 – hCYCC + CDK8 + inhibitor
    
• CYCD
  • 2w96, 2w99, 2w9f, 2w9z - hCYCD1 +CDK4 (mutant)
    
  • 6ei2 – hCYCD2 + HLA + microglobulin
    
  • 3g33 – hCYCD3 + CDK4
• CYCE
  • 1w98 – hCYCE1 + CDK2 T160P
    
  • 5l2w – hCYCE1 + CDK2 + drug
    
• CYCH
  • 1kxu, 1jkw – hCYCH
• CYCK
  • 2i53 – hCYCK N-terminal
    
  • 4un0 - hCYCK + CDK12 T160P
    
  • 4cxa - hCYCK + CDK12 T160P + AMPPNP
    
  • 5efq, 4nst - hCYCK + CDK13 T160P + ADP
    
  • 4un0, 5acb, 6b3e - hCYCK +CDK12 T160P + inhibitor
    
• CYCT
  • 3blh - hCYCT1 +CDK9
    
  • 3blq - hCYCT1 +CDK9+ATP
    
  • 4imy, 4or5, 4ogr - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4
    
  • 5l1z - hCYCT1 +CDK9 TPO160 +AMP + AF4/MRF2 family member 4 + RNA
    
  • 3lq5, 3tn8, 3tnh, 3tni, 4bcf, 4bcg, 4bch, 4bci, 4bcj – hCYCT1 (mutant)+CDK9
    
  • 3blr - hCYCT1 +CDK9+inhibitor
    
  • 3my1, 4ec8, 4ec9 - hCYCT1 (mutant)+CDK9 TPO160 +inhibitor
    
  • 3mi9, 3mia - hCYCT1 +CDK9+protein TAT
    
  • 2w2h - CYCT1 +protein TAT + RNA – horse
    
  • 2ivx – hCYCT2 (mutant)
• CYC
  • 2pk9 – yCYC PHO80 +CDK PHO85 – yeast
    
  • 2pmi - yCYC PHO80 +CDK PHO85+ATPgS
• Viral CYC
  • 2euf, 2f2c, 2xo2, 1jow – V-CYC+hCDK6 – Herpesvirus
    
  • 1bu2 – V-CYC
    
  • 1xo2 - V-CYC + hCDK6 + inhibitor
    
  • 1g3n - V-CYC +hCDK6+CDK6 inhibitor
    
  • 1f5q - V-CYC g +hCDK2

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