Sandbox GGC12
Structure: Human Interleukin-6
This is a default text for your page Sandbox GGC12. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. FunctionIL-6 is a cytokine known to have many functions which include stimulating cells that give rise to blood cells and cells that function in the immune system. IL-6 aids in the antibody-mediated immunity component of the adaptive immune system by targeting cells that secrete antibodies such as B lymphocytes. It also plays in cell-mediated immunity by targeting cells such as T lymphocytes. It turns and enhances the colony of cells producing blood cells. It also aids in the production of the proteins that flux in plasma concentration in response to inflammation, which are known as acute phase response proteins. DiseaseIL-6 has been found to be involved with the maintenance of bone homeostasis, as an increase in IL-6 levels has strongly reported in illnesses such as Paget’s disease and myeloma, where significant bone loss occurs. IL-6 has also been implicated in Castleman Disease. RelevanceIL-6 is produced is produced by wide range of cells that include not just cells of the immune system. Its production is induced by immune response, but can be affected by various antigenic factors. IL-6 binds to the IL-6 receptor of cells, which is then binded to the stignal-transducing receptor glycoprotein, known as gp130. This allows for the many functions of IL-6 in cells. Facilitating the roles that IL-6 plays in inducing cell growth and differentiation, other cytokines, immunoglobins, and acute phase proteins. Structural highlightsThis is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. The structure of IL-6 is composed of four helices: A, B, C, and D. Helices A and B run in opposite direction to helices C and D. Helix A is connected to B which is connected to C; then C is connected to D. Here you are able to get a clear view of the four helices that form IL-6. Here you are able to get a clear view of Helix A. Here you are able to get a clear view of Helix B. Here you are able to get a view of the water structure in the region between the D helix and the A-B loop of IL-6. The water molecules are shown as red spheres. The A-B loop is shown in brown with a yellow disulfide linkage near F74 which is displayed in pink. The D helix is shown in black. Q175 is shown in green. R179 is shown in blue.
Here you are able to get a clear view of the disulfide linkage between Helix A and Helix B.
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