Antigen 85

spinqualitylabelsall models Antigen 85C complex with detergent octylthioglucoside (PDB code 1va5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Antigens 85A, 85B and 85C posses mycolyltransferase activity and generate trehalose dimycolate which is an essential envelope lipid for Mycobacterium tuberculosis virulence. Inhibition of these enzymes hinders growth of the bacteria. The three enzymes show very high sequence identity (68-79%). Disease Antigen 85 proteins levels are elevated in tuberculosis patients. Structural highlights The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate. However, residues at the surface of the enzymes are different. Click here to see active site.

3D Structures of antigen 85

Updated on 08-May-2018

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• Antigen 85A
  • 1sfr – Mt85A – Mycobacterium tuberculosis
    
• Antigen 85B
  • 1f0n – Mt85B
    
  • 1f0p – Mt85B + tehalose
    
• Antigen 85C
  • 1dqz – Mt85C
    
  • 4mql, 4qdx, 4qdz, 4qe3, 4qek – Mt85C (mutant)
    
  • 1dqy – Mt85C + diethyl phosphate inhibitor
    
  • 4mqm, 4qdu – Mt85C + ebselen inhibitor
    
  • 4qdo – Mt85C + chloromercurybenzoate inhibitor
    
  • 4qdt – Mt85C + iodoacetamide inhibitor
    
  • 1va5 – Mt85C + octyl glucoside
    
  • 3hrh – Mt85C + glycerol
    

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