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Function
Dynactin (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.[1] See also CAP-Gly domain.
Disease
Mutant dynactin was found in motor neuron disease.[2]
Structural highlights
Dynactin subunit 1 CAP-Gly domain with the C-terminal domain of human EB1 (2hl5).[3]
- ↑ Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol. 1991 Dec;115(6):1639-50. PMID:1836789
- ↑ Puls I, Jonnakuty C, LaMonte BH, Holzbaur EL, Tokito M, Mann E, Floeter MK, Bidus K, Drayna D, Oh SJ, Brown RH Jr, Ludlow CL, Fischbeck KH. Mutant dynactin in motor neuron disease. Nat Genet. 2003 Apr;33(4):455-6. Epub 2003 Mar 10. PMID:12627231 doi:10.1038/ng1123
- ↑ Honnappa S, Okhrimenko O, Jaussi R, Jawhari H, Jelesarov I, Winkler FK, Steinmetz MO. Key interaction modes of dynamic +TIP networks. Mol Cell. 2006 Sep 1;23(5):663-71. PMID:16949363 doi:10.1016/j.molcel.2006.07.013
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3D Structures of Dynactin
Updated on 09-May-2018
CAP-Gly domain, 2hl5 - hDCTN subunit 1 CAP-Gly domain – human – NMR
2hkn - hDCTN subunit 1 CAP-Gly domain
3e2u – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1
2hkq, 2hl3, 1txq - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal
2hqh - hDCTN subunit 1 CAP-Gly domain + restin 2nd zinc finger domain
2hl5, 3tq7 - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal
2m02 - DCTN subunit 1 CAP-Gly domain – rat – NMR
3tv0 - hDCTN subunit 6
5adx – pDCTN subunits 2,3,5,6 + actin-related protein + actin + capping protein – pig – CryoEM
5afu, 5nw4 – pDCTN subunits 2,3,5,6 + dynein tail + capping protein – CryoEM
4rfx - DCTN subunit 1 coiled coil 1 domain (mutant) - chicken
References
