6dcn | pdb_00006dcn

Bcl-xL complex with Beclin 1 BH3 domain T108pThr

spinqualitylabelsall models 6dcn, resolution 2.44Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6dcn is a 4 chain structure. This structure supersedes the now removed PDB entry 5vb1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: TPO Related: 5vax, 5vau, 5vay Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis. [BECN1_HUMAN] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

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