6fxa | pdb_00006fxa

Dimerization domain of TP901-1 CI repressor

spinqualitylabelsall models 6fxa, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6fxa is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Related: 5a7l, 3zhi Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Temperate bacteriophages are known for their bistability, which in TP901-1 is controlled by two proteins, CI and MOR. Clear 1 repressor (CI) is hexameric and binds three palindromic operator sites via an N-terminal helix-turn-helix domain (NTD). A dimeric form, such as the truncated CI58 investigated here, is necessary for high-affinity binding to DNA. The crystal structure of the dimerization region (CTD1 ) is determined here, showing that it forms a pair of helical hooks. This newly determined structure is used together with the known crystal structure of the CI-NTD and small angle X-ray scattering data, to determine the solution structure of CI58 in complex with a palindromic operator site, showing that the two NTDs bind on opposing sides of the DNA helix. Structural basis of the bacteriophage TP901-1 CI repressor dimerization and interaction with DNA.,Rasmussen KK, Varming AK, Schmidt SN, Frandsen KEH, Thulstrup PW, Jensen MR, Lo Leggio L FEBS Lett. 2018 Apr 23. doi: 10.1002/1873-3468.13060. PMID:29683476 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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