5z14 | pdb_00005z14

Crystal structure of human TLR8 in complex with CU-CPT9a

spinqualitylabelsall models 5z14, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5z14 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 7VC, BMA, MAN, NAG Related: 5wyx, 5wyz Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

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