5cse | pdb_00005cse

Streptavidin-S112Y-K121E Complexed with Palladium-Containing Biotin Ligand

spinqualitylabelsall models 5cse, resolution 1.79Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5cse is a 2 chain structure with sequence from As 4.1583. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, SVP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). Publication Abstract from PubMed Introduction of a biotinylated monophosphine palladium complex within streptavidin affords an enantioselective artificial Suzukiase. Site-directed mutagenesis allowed the optimization of the activity and the enantioselectivity of this artificial metalloenzyme. A variety of atropisomeric biaryls were produced in good yields and up to 90% ee. The hybrid catalyst described herein shows comparable TOF to the previous aqueous-asymmetric Suzuki catalysts, and excellent stability under the reaction conditions to realize higher TON through longer reaction time. An enantioselective artificial Suzukiase based on the biotin-streptavidin technology.,Chatterjee A, Mallin H, Klehr J, Vallapurackal J, Finke AD, Vera L, Marsh M, Ward TR Chem Sci. 2016 Jan 1;7(1):673-677. doi: 10.1039/c5sc03116h. Epub 2015 Oct 19. PMID:29896353 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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