5oln | pdb_00005oln

X-Ray Structure of the Complex Pyrimidine-nucleoside phosphorylase from Bacillus subtilis at 1.88 A

spinqualitylabelsall models 5oln, resolution 1.88Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5oln is a 2 chain structure with sequence from Bacsu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, IMD, SO4 Related: 5ep8 Gene: pdp, BSU39400 (BACSU) Activity: Pyrimidine-nucleoside phosphorylase, with EC number 2.4.2.2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PDP_BACSU] Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.[UniProtKB:P77836] Publication Abstract from PubMed Pyrimidine-nucleoside phosphorylase catalyzes the phosphorolytic cleavage of thymidine and uridine with equal activity. Investigation of this protein is essential for anticancer drug design. Here, the structure of this protein from Bacillus subtilis in complex with imidazole and sulfate is reported at 1.9 A resolution, which is an improvement on the previously reported structure at 2.6 A resolution. The localization and position of imidazole in the nucleoside-binding site reflects the possible binding of ligands that possess an imidazole ring. Crystal structure of pyrimidine-nucleoside phosphorylase from Bacillus subtilis in complex with imidazole and sulfate.,Balaev VV, Prokofev II, Gabdoulkhakov AG, Betzel C, Lashkov AA Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):193-197. doi:, 10.1107/S2053230X18002935. Epub 2018 Mar 22. PMID:29633966 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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