6amp | pdb_00006amp

Crystal structure of H172A PHM (CuH absent, CuM present)

spinqualitylabelsall models 6amp, resolution 2.48Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6amp is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CU Related: 5wja, 5wkw, 5wm0, 6ala, 6alv Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [AMD_RAT] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

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