6ep3 | pdb_00006ep3

Lar controls the expression of the Listeria monocytogenes agr system and mediates virulence.

spinqualitylabelsall models 6ep3, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ep3 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, EPE, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The foodborne pathogen Listeria monocytogenes (Lm) causes invasive infection in susceptible animals and humans. To survive and proliferate within hosts, this facultative intracellular pathogen tightly coordinates the expression of a complex regulatory network that controls the expression of virulence factors. Here, we identified and characterized MouR, a novel virulence regulator of Lm. Through RNA-seq transcriptomic analysis, we determined the MouR regulon and demonstrated how MouR positively controls the expression of the Agr quorum sensing system (agrBDCA) of Lm. The MouR three-dimensional structure revealed a dimeric DNA-binding transcription factor belonging to the VanR class of the GntR superfamily of regulatory proteins. We also showed that by directly binding to the agr promoter region, MouR ultimately modulates chitinase activity and biofilm formation. Importantly, we demonstrated by in vitro cell invasion assays and in vivo mice infections the role of MouR in Lm virulence. MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence.,Pinheiro J, Lisboa J, Pombinho R, Carvalho F, Carreaux A, Brito C, Pontinen A, Korkeala H, Dos Santos NMS, Morais-Cabral JH, Sousa S, Cabanes D Nucleic Acids Res. 2018 Jul 12. pii: 5052370. doi: 10.1093/nar/gky624. PMID:30011022 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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