6g7i | pdb_00006g7i

Retinal isomerization in bacteriorhodopsin revealed by a femtosecond X-ray laser: 49-406 fs state structure

spinqualitylabelsall models 6g7i, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6g7i is a 1 chain structure with sequence from Halsa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: LI1, OLC, RET Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [BACR_HALSA] Light-driven proton pump. Publication Abstract from PubMed Ultrafast isomerization of retinal is the primary step in photoresponsive biological functions including vision in humans and ion-transport across bacterial membranes. We studied the sub-picosecond structural dynamics of retinal isomerization in the light-driven proton pump bacteriorhodopsin using an x-ray laser. A series of structural snapshots with near-atomic spatial and temporal resolution in the femtosecond regime show how the excited all-trans retinal samples conformational states within the protein binding pocket prior to passing through a twisted geometry and emerging in the 13-cis conformation. Our findings suggest ultrafast collective motions of aspartic acid residues and functional water molecules in the proximity of the retinal Schiff base as a key ingredient for this stereo-selective and efficient photochemical reaction. Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser.,Nogly P, Weinert T, James D, Carbajo S, Ozerov D, Furrer A, Gashi D, Borin V, Skopintsev P, Jaeger K, Nass K, Bath P, Bosman R, Koglin J, Seaberg M, Lane T, Kekilli D, Brunle S, Tanaka T, Wu W, Milne C, White T, Barty A, Weierstall U, Panneels V, Nango E, Iwata S, Hunter M, Schapiro I, Schertler G, Neutze R, Standfuss J Science. 2018 Jun 14. pii: science.aat0094. doi: 10.1126/science.aat0094. PMID:29903883 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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