Merlin

spinqualitylabelsall models Mouse merlin FERM domain (grey) complex with HIV-1 Vpr-binding protein C-terminal (gold) (PDB code 3wa0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Merlin (Mer) or Moesin-exrin-radixin-like protein is a unique tumor suppressor that inhibits mitogenic signaling at the membrane-cytoskeleton interface. The FERM domain of Mer regulates cell proliferation in response to adhesive signaling. Disease Neurofibromatosis type 2, characterized by tumors of the nervous system, is the result of loss of the NF2 gene which encodes Mer. Structural highlights The binding of Mer FERM domain to the C-terminal of HIV-1 Vpr-binding protein results in the inhibition of Mer-mediated suppression of tumorigenesis. The interactions between the proteins are formed by the α-helix and a β-sheet of Mer and a mostly β-sheet of HIV-1 Vpr-binding protein.

3D Structures of merlin

Updated on 06-August-2018

3u8z, 1h4r – hMer FERM domain – human
6cds – hMer FERM domain (mutant)
4zrj – hMer FERM + C-terminal domain (mutant)
1isn – mMer FERM domain - mouse
3wa0 – mMer FERM domain + HIV-1 Vpr-binding protein residues 1417-1506
4p7i – mMer FERM domain + HIV-1 Vpr-binding protein residues 998-1058
4zrk – mMer FERM domain + Lats1 peptide
4zri – hMer FERM domain + Lats2 peptide

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Michal Harel, Joel L. Sussman