| Function
Netrin receptors are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. Netrin attraction is mediated through DCC (Deleted in Colorectal Cancer) receptors while netrin repulsion is mediated through the UNC-5 receptor[1].
Disease
DCC gene is deleted in most colorectal cancer patients as well as in other cancers[2].
Structural highlights
Netrin DCC receptor extracellular domain contains 4 Ig repeats followed by 6 type III fibronectin repeats. Netrin UNC-5 receptor extracellular domain contains 2 Ig repeats followed by 2 type I thrombospondin repeats.
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3D Structures of netrin receptor
Updated on 13-August-2018
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- Netrin receptor DCC; domains – FN1 419-524; FN2 528-620; FN3 602-718; FN4 716-818; FN5 833-942; FN6 944-1044; P3 1390-1447.
- 2ed7 – hDCC first fibronectin type III domain – human - NMR
- 2ed8 – hDCC second fibronectin type III domain - NMR
- 2ed9 – hDCC third fibronectin type III domain - NMR
- 2edb – hDCC fourth fibronectin type III domain - NMR
- 2edd – hDCC fifth fibronectin type III domain - NMR
- 2ede – hDCC sixth fibronectin type III domain - NMR
- 3au4 – hDCC P3 motif + myosin-X
- 6bz3 – hDCC P3 motif + focal adhesion kinase FAT domain
- 4urt – hDCC fibronectin type V-VI domains + neutrin-1
- 5x83 – hDCC fibronectin 4-6 domains
- 4plo – mDCC fourth fibronectin type IV domain + neutrin-1 - mouse
- 3pzd – mDCC P3 motif + myosin-X
- 3laf – rDCC residues 39-421 - rat
- 5z5k – rDCC residues 39-421 + draxin peptide
- Netrin receptor UNC5A
- Netrin receptor UNC5B
- 3g5b – rUNC5B cytoplasmic domain (mutant)
- Netrin receptor UNC5D
- 4v2b – rUNC5D Ig1 domain
- 4v2c – rUNC5D Ig1 domain + FLRT2 LRR domain
- 5ftt, 5ftu – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3
- Netrin receptor UNC5H2
- 1wmg – mUNC5H2 death domain
References
