Nucleoporin

spinqualitylabelsall models Yeast nucleoporin NUP159 N-terminal domain (PDB entry 1xip) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD). NUP1P is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture. NUP2P is a yeast nucleoprotein required for bidirectional transport of importin α. NUP Gle1 is a yeast and human nucleoprotein required mRNA export. Disease NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids.

3D Structures of Nucleoporin

Updated on 15-August-2018

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• NUP2
  • 3n7c – NUP2 RANBD – Ashbya gossypii
    
  • 2c1t – yNUP2 NTD +importrin alpha subunit - yeast
    
• NUP35
  • 1wwh – mNUP35 MPPN domain - mouse
    
• NUP37
  • 4fhl – fyNUP37 – fission yeast
    
  • 4fhm, 4fhn, 4gq2 - fyNUP37 + NUP120
    
• NUP43
  • 4i79 – hNUP43 + polypeptide
    
• NUP50
  • 2ec1 – hNUP50 RANBD - human
    
  • 2c1m – mNUP50 NTD +importin
    
  • 3tj3 - hNUP50 NTD+importin
    
• NUP53
  • 3p3d - NUP53 RRM domain - Pischia guillermondii
    
  • 4lir – hNUP53 residues 151-266
    
  • 5uaz – yNUP53
    
  • 5hb8, 5hb7 – CtNUP53 - Chaetomium thermophilum
    
  • 5hb3 – CtNUP53 + NUP NIC96
    
• NUP54
  • 3t97 – rNUP54 + NUP62 - rat
    
  • 4j3h – rNUP54 (mutant)
    
  • 3t98 – rNUP54 + rNUP58/45
    
  • 4jo7, 4jo9 – hNUP54 + hNUP58/45
    
  • 5c3l – NUP54 coiled coil + NUP58 coiled coil + NUP62 coiled coil + nanobody - frog
    
• NUP57
  • 5cwt – CtNUP57 residues 265-317
    
  • 5cws – CtNUP57 residues 74-319 + NUP49 + NIC96 + antibody
    
• NUP58
  • 2osz – rNUP58/45
    
  • 4jq5 – hNUP58/45
    
• NUP62
  • 5h1x – rNUP62 coiled-coil domain
    
• NUP82
  • 3pbp – yNUP82 NTD + NUP116 CTD + NUP159 CTD
    
  • 3tkn - yNUP82 NTD + NUP98 + NUP159 CTD
    
  • 5cww – CtNUP82 + CtNUP145 CTD peptide + Ct159 CTD peptide
    
• NUP84
  • 3jro, 3iko – yNUP84+NUP145+protein Sec13
    
  • 4xmm - yNUP84+NUP85+NUP120+NUP145+protein Seh1 + antibody
    
  • 4xmn - yNUP84+NUP85+NUP120+NUP145 + antibody
    
• NUP85
  • 3f3f, 3f3g, 3f3p, 3ewe – yNUP85+Seh1
    
• NUP98
  • 3mmy – hNUP98 fragment+mRNA export factor
    
  • 2q5x, 2q5y – hNUP98 CTD
    
  • 1ko6 – hNUP98 CTD
    
• NUP100
  • 3nf5 – NUP100 CTD – Candida glabrata
    
• NUP107
  • 3i4r, 3cqc, 3cqg – hNUP107+NUP133
    
• NUP116
  • 2aiv – yNUP116 CTD - NMR
    
• NUP120
  • 3f7f, 3h7n, 3hxr – yNUP120
    
• NUP133
  • 1xks, 4q9t – hNUP133 NTD
    
  • 3kfo – yNUP133 CTD
    
• NUP145
  • 3bg0, 3bg1 – hNUP145+Sec13-related protein
    
  • 3kep, 3kes – yNUP145 autoproteolytic domain
    
  • 3jrp - yNUP145+protein Sec13
    
  • 5hb5 – CtNUP145
    
  • 5hb6 – CtNUP145 (mutant)
    
• NUP152
  • 5tvz – yNUP152 Ig-like repeats - NMR
    
• NUP153
  • 3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8, 3ch5 – hNUP153+RAN
    
  • 2ebq, 2ebr, 2ebv, 2gqe - hNUP153 RANBD – NMR
    
  • 2k0c – rNUP153 RANBD – NMR
    
• NUP157
  • 4mhc – hNUP157 NTD
    
• NUP159
  • 1xip – yNUP159 NTD
    
  • 3rrm – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP
    
• NUP170
  • 3i5p, 3i5q – yNUP170
    
  • 5hb1 – CtNUP170
    
  • 5haz – CtNUP170 CTD
    
  • 5hay – CtNUP170 CTD (mutant)
    
  • 5hb0 – CtNUP170 (mutant) + CtNUP145 peptide
    
  • 5hax – CtNUP170 NTD + CtNUP53 peptide
    
• NUP188
  • 5cwu – CtNUP192 tail domain
    
• NUP192
  • 4ifq – yNUP192
    
  • 5hb4 – CtNUP192
    
  • 5cwv – CtNUP192 tail domain
    
• NUP214
  • 3fmo, 3fmp, 3fhc – hNUP214+dead-box helicase
    
  • 2oit – hNUP214 NTD
    
• NUP358
  • 1z5s – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD
    
  • 1xke - hNUP358 RANBD - NMR
    
• NUP1P
  • 5owu – NUP1P+Kap95 complex
    
• NUP2P
  • 1un0 – yNUP2P NTD+importrin α subunit
    
• NUP-NSP1
  • 1o6o – yNUP-NSP1 residues 497-608+importrin β subunit
    
• NUP-CDC31
  • 2doq, 2gv5 – yNUP-CDC31+SFI1P
    
  • 3fwb, 3fwc - yNUP-CDC31+SAC3
    
• NUP Gle1
  • 3peu, 3pev, 3rrn– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6
    
  • 6b4e – yNUP-Gle1 + NUP42
    
  • 6b4g, 6b4h – CtNUP-Gle1 + NUP Amo1
    
• Nuclear pore complex
  • 5ijo, 5ijn – hNUP93 + NUP155 + NUP205 + NUP54 + NUP58 + NUP62 + NUP188 – Cryo EM
    
  • 5a9q – hNUP96 + NUP133 + NUP160 + NUP43 + NUP37 + NUP85 + NUP155 + NUP107 + Sec13 + Seh1 – Cryo EM
    
  • 2rfo, 2qx5 – yNic96
    
  • 5hb2 – CtNic96
    
  • 1gyb – NUP+yNTF2
    

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Alexander Berchansky, Jaime Prilusky, Joel L. Sussman, Michal Harel