Parvalbumin

spinqualitylabelsall models Pike parvalbumin complex with Ca+2 ions (green), ammonium ion (blue), acetyl and formate (PDB entry 2pvb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Parvalbumin (PVA) is a calcium-binding albumin protein. PVA is involved in calcium signaling. PVA contains 3 domains each containing 2 helices: AB, CD (N-terminal) and EF (C-terminal). α-parvalbumin differs from β-parvalbumin in 54 positions. α-parvalbumin is expressed in various tissues while β-parvalbumin is expressed only in preterm placenta. See also EF hand Parvalbumin carp. Relevance PVA is a major fish allergen. Structural highlights PVA contains a heptacoordinated Ca+2 ion binding to 7 oxygen atoms in a typical EF-hand coordination. Calcium ion is coordinated by seven oxygen atoms that form a pentagonal bipyramid . Ammonium ion coordination site. Water molecules shown as red spheres.

3D Structures of Parvalbumin

Updated on 16-August-2018

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• parvalbumin
  • EF hand, Parvalbumin carp – cPVA - carp
    
  • 1cdp – cPVA Cd-substituted
    
  • 1b8c, 1b8r, 1b9a, 1b8l – cPVA (mutant)
    
  • 1pal, 2pal, 3pal, 4pal, 1pvb, 1pva, 2pvb – pPVA – pike
    
  • 2pas, 3pat – pPVA – NMR
    
  • 1a75 – PVA – whiting
    
  • 1bu3 – PVA Ca-binding domain – hake
    
  • 5zgm – MgPVA SPV-I – Mustelus griseus
    
  • 5zh6 – MgPVA SPV-II
    
• α-parvalbumin
  • 5pal – PVA-α - shark
    
  • 1rtp, 1rwy - rPVA-α - rat
    
  • 2jww - rPVA-α Ca-free – NMR
    
  • 1g33, 1s3p, 1xvj, 3f45 - rPVA-α (mutant)
    
  • 1rjv, 1rk9 - hPVA-α - human – NMR
• β-parvalbumin (oncomodulin)
  • 2nln - rPVA-β Ca-free – NMR
    
  • 1rro, 1omd - rPVA-β
    
  • 1ttx - hPVA-β (mutant) – NMR
    
  • 3fs7 - chPVA-β - chicken
    
  • 2kqy – chPVA-β – NMR
    
  • 2kyc - chPVA-β
    
  • 2kyf - chPVA-β (mutant) – NMR
    
  • 2mbx - PVA-β – cod - NMR
    
  • 5xnd - PVA-β – mackerel - NMR
    

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Alexander Berchansky, Michal Harel, Joel L. Sussman