Profilin

spinqualitylabelsall models Human profilin I (green) complex withα-actin (grey), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code 2pbd) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Profilin (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes. Disease PFN from birch, peanut and other plants is a major allergen.

3D Structures of profilin

Updated on 26-August-2018

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• Profilin I
  • 1fik, 1fil, 4x1l – hPFN – human
    
  • 1pfl – hPFN - NMR
    
  • 4x25, 4x1m – hPFN (mutant)
    
  • 1pne – bPFN – bovine
    
  • 1cqa – biPFN - birch
    
  • 3nul, 1a0k – PFN – Arabidopsis thaliana
    
  • 1ypr, 1k0k – PFN - yeast
    
  • 3d9y, 3dav – PFN – fission yeast
    
  • 1g5u – PFN – Hevea brasiliensis
    
  • 2jkf, 4d60 – PfPFN – Plasmodium falciparum
    
  • 4esp – PFN – peanut
    
  • 4qwo – PFN – monkeypox virus
    
  • 2prf – AcPFN – Acanthamoeba castellanii - NMR
    
  • 1prq – AcPFN
    
  • 3nec – PFN – Toxoplasma gondii
    
  • 5fef - PFN - maize
    
  • 5em0 - PFN - mugwort
    
  • 5em1 - rPFN - ragweed
    
• Profilin I complex
  • 2btf, 3u4l, 3ub5 – bPFN + β-actin
    
  • 1hlu – bPFN + β-actin + ATP
    
  • 2jkg – PfPFN + poly-Pro peptide
    
  • 5ev0, 5eve - rPFN + poly-Pro peptide
    
  • 1awi, 1cf0, 1cjf – hPFN + poly-Pro peptide
    
  • 2pav, 2pbd, 3chw – hPFN + α-actin + VASP poly-Pro peptide + ATP
    
• Profilin II
  • 1acf, 2acg, 1f2k – AcPFN
    
  • 1d1j – hPFN
    
  • 2vk3 – PFN - rat
    
  • 5fds, 5feg - PFN - rubber tree
    
  • 2v8c – mPFN + VASP poly-Pro peptide - mouse
    
  • 2v8f – mPFN + MDIA1 poly-Pro peptide
    
  • 5nzb, 5nzc – biPFN
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel