Protein Nef

spinqualitylabelsall models HIV-I protein Nef (grey) complex with tyrosine protein kinase Hck SH3 domain (green) and ethanediol (PDB code 3rbb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Protein Nef (Nef) or negative regulatory factor is an HIV and SIV accessory protein which establishes a persistent state of infection. Nef downmodulates the surface levels of molecules at the immune synapse. For more details see HIV and accessory proteins.

3D Structures of protein Nef

Updated on 29-August-2018

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• Protein Nef from HIV; domains – anchor 1-57; core 58-207
  • HIV and accessory proteins, 2xi1 – Nef – HIV-1
    
  • 1qa5, 1qa4 – Nef anchor domain – NMR
    
  • 1avv, 6b72 – Nef core domain
    
  • 2nef – Nef core domain (mutant) – NMR
    
• Protein Nef from HIV complex
  • 4u5w, 3rbb – Nef core domain + tyrosine protein kinase Hck
    
  • 3rea, 3reb – Nef core domain (mutant) + tyrosine protein kinase Hck
    
  • 4d8d, 1avz, 1efn – Nef core domain + tyrosine protein kinase Fyn
    
  • 4orz – Nef core domain + tyrosine protein kinase Hck + single domain antibody
    
  • 4u5w - Nef core domain + tyrosine protein kinase Hck SH3-SH2 domain
    
  • 4nee – Nef core domain + adapter-related protein complex 2 subunits σ, α-2
    
  • 4emz, 4en2 – Nef + adapter-related protein complex 1 subunit μ-1 + MHC-I
    
• Protein Nef from SIV
  • 3ik5, 3ioz – Nef core domain + CD3 ζ
    
  • 5nuh - Nef core domain + tyrosine protein kinase Hck SH3 domain
    
  • 5nui - Nef core domain + polypeptide
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel