5ou8 | pdb_00005ou8

Crystal structure of Glycoprotein VI in complex with collagen-peptide (GPO)5

spinqualitylabelsall models 5ou8, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5ou8 is a 5 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, NAG, PG4 NonStd Res: HYP Related: 5ou7 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [GPVI_HUMAN] Bleeding diathesis due to glycoprotein VI deficiency. The disease is caused by mutations affecting the gene represented in this entry. Function [GPVI_HUMAN] Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

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