5yav | pdb_00005yav

Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction

spinqualitylabelsall models 5yav, resolution 1.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5yav is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 8SF Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).

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