5naz | pdb_00005naz

Crystal structures of homooligomers of collagen type IV. alpha5NC1

spinqualitylabelsall models 5naz, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5naz is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, PG4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [CO4A5_HUMAN] X-linked diffuse leiomyomatosis - Alport syndrome;X-linked Alport syndrome. The disease is caused by mutations affecting the gene represented in this entry. Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are found in the chromosome Xq22.3 centromeric deletion syndrome. This results in a phenotype with features of diffuse leiomyomatosis and Alport syndrome (DL-ATS). Function [CO4A5_HUMAN] Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

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