Selectin

spinqualitylabelsall models Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry 1g1r) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Selectin or CD62 are cell adhesion molecules which bind sugar moieties and thus are regarded as lectins. The structure of selectin consists of extracellular calcium-dependent lectin domain, an EGF-like domain and a number of concensus repeat units, a transmembranal domain and a intracellular domain. Three types of selectins are found: E-selectin found in endothelial cells L-selectin found in leukocytes P-selectin found in platelets. Relevance Selectins are involved in inflammation processes. The L-selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the blood vessel walls, slowing their motion and enabling them to enter the site of infection. E-selectin levels correlate with disease activity in psoriasis patients. L-selectin levels correlate with disease activity in type I diabetes. Structural insight The tetrasaccharide binding interactions to P-selectin are electrostatic. Ca coordination site.

3D structures of selectin

Updated on 17-September-2018

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• P-selectin
  • 1fsb – hCD62P EGF domain – human - NMR
    
  • 1g1q – hCD62P EGF domain
    
  • 1g1r – hCD62P EGF domain + tetrasaccharide
    
  • 1g1s – hCD62P EGF domain +P-selectin glycoprotein ligand peptide
    
  • 4gxb – hCD62P intracellular domain + sorting nexin-17
    
• L-selectin
  • 3cfw – hCD62L EGF domain
    
  • 5vc1 – hCD62L EGF domain (mutant)
    
  • 2lgf – hCD62L calmodulin-binding domain + calmodulin
    
• E-selectin
  • 1esl – hCD62E EGF domain
    
  • 1g1t – hCD62E EGF domain + tetrasaccharide
    
  • 4c16 – hCD62 EGF+SCR domains + antagonist
    
  • 4csy – hCD62 EGF+SCR domains + ligand
    

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Michal Harel, Alexander Berchansky