TATA-Binding Protein

spinqualitylabelsall models Human TATA-binding protein complex with DNA TATA box (PDB code 1tgh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function TATA-Binding Protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation. Called the TATA box to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also Transcription and RNA Processing Yeast TATA Binding Protein. Additional information See: Transcription for additional Proteopedia resources Relevance TBP is associated with aggregated proteins in several of the polyglutamine disorders like cerebellar ataxia. Structural highlights interact with the phosphate groups phenylalanine amino acids asparagine amino acids two symmetrical halves. The interactions of TBP with the DNA TATA box occurs with the minor groove of the DNA. The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic.

3D Structures of TATA-binding protein

Updated on 24-September-2018

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• TBP
  • Transcription and RNA Processing – TBP – Methanococcus janaschii
    
  • Yeast TATA Binding Protein – PwTBP - Pyrococcus woesei
    
  • Transcription – AtTBP - Arabidopsis thaliana
    
  • 1tbp – yTBP - yeast
    
  • 4b04 – yTBP (mutant)
    
  • 1mp9 – TBP – Sulfolobus acidocaldarius
    
  • 3eik – TBP – Encephalitozoon cuniculi
• TBP+DNA TATA box
  • 1ytb - yTBP + DNA TATA
    
  • 1cdw - hTBP core domain+ DNA TATA - human
    
  • 1tgh - hTBP + DNA TATA
    
  • 1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne, 1qn3, 1qn4, 1vto - AtTBP + DNA TATA
    
• TBP+DNA TATA box +TFIIA
  • 1rm1 – yTBP+TFIIA α, β, γ chains+ DNA TATA
    
  • 1ytf - yTBP+TFIIA + DNA TATA
    
  • 1nh2 – yTBP C-terminal+TFIIA α, β, γ chains+ DNA TATA
    
  • 1nvp - hTBP C-terminal+ TFIIA α, β, γ chains+ DNA TATA
    
  • 1jfi - hTBP C-terminal+ TFIIA NC2+ DNA TATA
    
• TBP+DNA TATA box +TFIIB
  • 1tba – yTBP core domain+TAFII230 fragment - NMR
    
  • 1c9b - hTBP C-terminal+TFIIBC+adenovirus major late promoter
    
  • 1vol – AtTBP+hTFIIB+DNA TATA
    
  • 1ais, 1d3u - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA
    
  • 1tba – yTBP core domain+TAFII230 fragment - NMR
    
• TBP+DNA TATA+TFIIIB
  • 1ngm - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA
    
  • 4roc, 4rod, 4roe, 5n9g - hTBP + TFIIIB + DNA TATA
    
• TBP+DNA TATA+TFIIA+TFIID
  • 5fur - yTBP +TFIIB + TFIID + DNA TATA
    
• TBP in RNA polymerase II complex
  • 5fyw, 5fz5, 5fmf, 4v1n, 4v1o, 5sva, 5oqj, 5oqm – yTBP + DNA-directed RNA polymerase II + TFII + DNA - Cryo EM
    
  • 5iy6, 5iy7, 5iy8, 5iy9, 5iya, 5iyb, 5iyc, 5iyd – hTBP + DNA-directed RNA polymerase II + TFII + DNA - Cryo EM
    

Proteopedia Page Contributors and Editors (what is this?)

Ala Jelani, Alexander Berchansky, David Canner, Michal Harel, Eran Hodis