Thermolysin

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Thermolysin (TML) is a thermostable metalloproteinase enzyme from Bacillus thermoproteolyticus. It catalyzes the hydrolysis of peptide bonds containing hydrophobic residues. See Metalloproteases and Matrix metalloproteinase for discussion. Structural highlights Thermolysin is a well researched metalloprotease containing zinc (click this!) and the amino acids His-Glu-X-His-His as its catalytic center. Glu-166, His-142 and -146 are grouped around the zinc atom, holding it fast, while Glu-143 holds the polarized water atom. Additionally, Tyr-157 and His-231 stabilize the substrate protein which will be cleaved into two smaller proteins..

3D Structures of Thermolysin

Updated on 25-September-2018

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• Thermolysin
  • Metalloproteases, Matrix metalloproteinase, metalloprotease, 3do0, 3do1, 3do2, 2g4z, 2a7g, 1gxw, 1kei, 1l3f, 1tlx, 2tlx, 8tln, 3p7p, 3p7q, 3p7r, 3p7s, 3p7t, 3p7u, 3p7v, 3p7w, 3zi6, 5dlh, 5tli, 6tli, 7tli, 8tli, 5un3, 5uu7, 5wr2, 5wr3, 5wr4, 5wr5, 5wr6, 5a3y, 5o8n, 5uu8, 5uu9, 5uua, 5uub, 5uuc, 5uud, 5uue, 5fsj, 5fsp, 5fss, 5fxn, 5t9i, 5t9k, 5t9q, 5tac, 5tad, 5tae, 5tai, 5taj, 5tak, 5hqd, 6tli, 7tli, 8tli, 6d5o, 6fsm, 6d5p, 6d5q, 6d5r, 6d5s, 6d5t, 6d5u, 6fj2 – TML
    
  • 5dlh – TML - electron crystallography
    
  • 3ls7, 4ow3, 4tnl - TML residues 233-548
    
  • 1trl - TML residues 255-316 – NMR
    
  • 3fxs, 3fbo, 3eim, 1lna, 1lnb, 1lnc, 1lnd, 1lne, 1lnf - TML residues 233-548+metal ion replacing Ca
    
• Thermolysin TML+transition state analog
  • 1tlp, 1tmn, 2tmn, 4tmn, 5tmn – TML+transition state analog
    
• Thermolysin + amino acid
  • 1kl6 – TML+ alanine
    
  • 4m65 – TML + asparagine
    
  • 8tln – TML+ avaline + lysine
    
  • 3qgo – TML + phenylalanine methyl ester
    
  • 3qh1 – TML + benzyloxycarboxyl- aspartate
    
  • 3qh5 – TML + benzyloxycarboxyl- aspartate + phenylalanine methyl ester
• Thermolysin + dipeptide
  • 2wi0, 3tmn, 8tln – TML+ dipeptide
    
  • 3fgd - TML residues 233-548+dipeptide
    
• Thermolysin + inhibitor
  • 1fjo, 1fj3, 1fjq, 1fjt, 1fju, 1fjv, 1fjw, 4tli, 5tli, 6tli, 7tli, 8tli, 1tli, 2tli, 3tli – TML soaked in organic solvents
    
  • 3fv4, 3fxp, 3flf, 3fb0, 3fcq, 3f28, 3f2p, 4mtw, 4mwp, 4mxj, 4mzn, 4n4e, 4n5p, 4n66, 4oi5 – TML residues 233-548+inhibitor
    
  • 3for, 1y3g, 1zdp, 1z9g, 1pes, 1pe7, 1pe8, 1os0, 1kto, 1ks7, 1kro, 1kr6, 1kkk, 1kjo, 1kjp, 1qf0, 1qf1, 1qf2, 1hyt, 1thl, 6tmn, 7tln, 4tln, 5tln, 1pe5, 3ms3, 3msa, 3msf, 3msn, 3n21, 3nn7, 3t73, 3t74, 3t87, 3t8c, 3t8d, 3t8f, 3t8g, 3t8h, 4h57, 4d9w, 4d91, 5dpe, 5dpf, 5js3, 5jss, 5jt9, 5jvi, 5jxn, 5lif, 5lvd, 5lwd, 5m5f, 5m69, 5mnr, 5n2t, 5n2x, 5n2z, 5n31, 5n34, 5n3v, 5n3y, 5ma7, 5l3u, 5l41, 5l8p, 5m9w, 6tmn, 7tln, 5tln, 5tmn, 5wr2, 5wr3, 5wr4, 5wr5, 5wr6 – TML+inhibitor
    
  • 3ssb – TML + Impi-α
    
  • 3t2h – TML + trimethylamine oxide
    
  • 3t2i – TML + sarcosine
    
  • 3t2j – TML + betaine
    
  • 6fhp – TML C terminal + DAIP
    

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Alexander Berchansky, Michal Harel