Tryptase

spinqualitylabelsall models Human tryptaseβ-2 tetramer complex with piperidine derivative inhibitor, 2zeb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Tryptase (TRP) is a serine protease found in mast cells. Relevance TRP is used as a marker for mast cell activation. Inhibitors of TRP have therapeutic potential for treating allergic or inflammatory disorders such as asthma and inflammatory bowel diseases. Structural highlights The biological assembly of Human tryptase is homotetramer (2zeb). The piperidine derivative TRP inhibitor interacts with both subunits of TRP. Water molecules shown as red spheres.

3D Structures of tryptase

Updated on 27-September-2018

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• Tryptase
  • 2zeb – hTRP-α1 - human
    
  • 2f9o - hTRP-α1 (mutant)
    
  • 5wi6 - hTRP-α/β1 (mutant)
    
• Tryptase complex with inhibitor
  • 1a0l – hTRP-β + APPA
    
  • 2f9n, 2f9p - hTRP-α1 (mutant) + leupeptin
    
  • 2bm2, 2fww - hTRP-β2 + piperidine derivative
    
  • 5f03 - hTRP-β2 + oxazolidine derivative
    
  • 4a6l - hTRP-α/β1 + piperidine derivative
    
  • 4mpu, 4mpv, 4mpw, 4mpx, 4mqa - hTRP-α/β1 + drug
    
  • 2fxr - hTRP-β2 + ketone inhibitor
    
  • 2fpz - hTRP-β2 + benzimidazole inhibitor
    
  • 2fs9, 2fs8, 2gdd, 2za5, 2zeb, 2zec - hTRP-β2 + inhibitor
    
  • 3v7t - hTRP-β2 + tropanylamide inhibitor
    

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Michal Harel, Alexander Berchansky